Testing Differences Between Sets of Abundance Profiles in Metagenomics
(11/25/2013) 9 minutes


Advances in genomic technologies have enabled the exploration of the composition and diversity of microbial communities based on microbial DNA using metagenomic tools and approaches. In recent years, focus has shifted from describing the composition and diversity of various communities to studies that compare the microbiome in different environments or in individuals with and without a disease. These kinds of studies require rigorous statistical techniques that test hypotheses regarding differences in microbial composition between sets of samples. However, metagenomic data has several characteristics that complicate its analysis via standard statistical methods, including high dimensionality.

more on this subject: